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American Journal of Critical Care. 2009;18: 388-386 doi:10.4037/ajcc2009100
Copyright © 2009 by the American Association of Critical-Care Nurses.
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Cases of Note features peer-reviewed case reports and case series that document clinically relevant findings from critical and high acuity care environments. Cases that illuminate a clinical diagnosis or a management issue in the treatment of critically and acutely ill patients and include discussion of the patient’s experience with the illness or intervention are encouraged. Proposals for future Cases of Note articles may be e-mailed to ajcc{at}aacn.org.

Acute ST-Segment Elevation Myocardial Infarction Associated With Diclofenac-Induced Anaphylaxis: Case Report

By J. W. B. de Groot, MD, PhD, A. T. M. Gosselink, MD, PhD and J. P. Ottervanger, MD, PhD. J. W. B. de Groot, A. T. M. Gosselink, and J. P. Ottervanger are all physicians in the Department of Cardiology at Isala klinieken Zwolle in The Netherlands.

Corresponding author: J. P. Ottervanger, MD, PhD, Department of Cardiology, Isala klinieken, Groot Wezenland 20, 8011 JW Zwolle, The Netherlands (e-mail: v.r.c.derks{at}isala.nl).

A patient in whom acute myocardial infarction developed during diclofenac-induced anaphylaxis is described. ST-segment elevation myocardial infarction is a rare complication of anaphylactic reactions, but can occur even in patients with angiographically normal coronary arteries. Physicians should be aware of such a complication in order to diagnose it early and treat it properly. In the patient described here, according to the temporal relationship with diclofenac intake and the exclusion of coronary stenosis, it is probable that diclofenac caused the symptoms. To our knowledge, this is the first reported case of Kounis syndrome due to diclofenac. The patient’s recovery was uneventful.







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Copyright © 2009 by the American Association of Critical-Care Nurses.